Research Impact - HERON, Greater Plains Collaborative, and Frontiers initiatives

Our work in developing HERON (i2b2) and Frontiers (CTSA Grant Number UL1TR000001) is described in the following publication - 
 
Waitman LR, Warren JJ, Manos EL, Connolly DW. Expressing observations from electronic medical record flowsheets in an i2b2 based clinical data repository to support research and quality improvement. AMIA Annu Symp Proc. 2011;2011:1454-63. Epub 2011 Oct 22. PubMed PMID: 22195209; PubMed Central PMCID: PMC3243191
 
The following publications cite our HERON/Frontiers efforts:
  • Whiles BB, Deis AS, Simpson SQ. Increased Time to Initial Antimicrobial Administration Is Associated With Progression to Septic Shock in Severe Sepsis Patients. Crit Care Med. 2017 Apr;45(4):623-629. doi:10.1097/CCM.0000000000002262. PubMed PMID: 28169944; PubMed Central PMCID: PMC5374449

  • Zhou L, Collins S, Morgan SJ, Zafar N, Gesner EJ, Fehrenbach M, Rocha RA. A Decade of Experience in Creating and Maintaining Data Elements for Structured Clinical Documentation in EHRs. AMIA Annu Symp Proc. 2017 Feb 10;2016:1293-1302.  eCollection 2016. PubMed PMID: 28269927; PubMed Central PMCID: PMC5333263

  • Britt NS, Patel N, Shireman TI, El Atrouni WI, Horvat RT, Steed ME. Relationship between vancomycin tolerance and clinical outcomes in Staphylococcus aureus bacteraemia. J Antimicrob Chemother. 2016 Dec 20. pii: dkw453. doi: 10.1093/jac/dkw453. [Epub ahead of print] PubMed PMID: 27999028

  • Oertel MJ, Graves L, Al-Hihi E, Leonardo V, Hopkins C, DeSouza K, Bhattacharya  RK. Osteoporosis management in older patients who experienced a fracture. Clin Interv Aging. 2016 Aug 22; 11:1111-6. doi: 10.2147/CIA.S107720. eCollection 2016.  PubMed PMID: 27578967; PubMed Central PMCID: PMC5001657

  • Pruinelli L, Yadav P, Hangsleben A, Johnson J, Dey S, McCarty M, Kumar V, Delaney CW, Steinbach M, Westra BL, Simon GJ. A Data Mining Approach to Determine Sepsis Guideline Impact on Inpatient Mortality and Complications. AMIA Jt Summits Transl Sci Proc. 2016 Jul 20; 2016:194-202. eCollection 2016. PubMed PMID: 27570669; PubMed Central PMCID: PMC5001751

  • Westra BL, Christie B, Johnson SG, Pruinelli L, LaFlamme A, Park JI, Sherman SG, Byrne MD, Ranallo P, Speedie S. Expanding Interprofessional EHR Data in i2b2. AMIA Jt Summits Transl Sci Proc. 2016 Jul 20;2016:260-8. eCollection 2016. PubMed PMID: 27570680; PubMed Central PMCID: PMC5001775

  • Matney SA, Settergren TT, Carrington JM, Richesson RL, Sheide A, Westra BL. Standardizing Physiologic Assessment Data to Enable Big Data Analytics. West J Nurs Res. 2016 Jul 18. pii: 0193945916659471. [Epub ahead of print] PubMed PMID:  27435084

  • Sisante JV, Abraham MG, Phadnis MA, Billinger SA, Mittal MK. Ambulatory Status Protects against Venous Thromboembolism in Acute Mild Ischemic Stroke Patients. J Stroke Cerebrovasc Dis. 2016 Jul 13. pii: S1052-3057(16)30144-6. doi: 10.1016/j.jstrokecerebrovasdis.2016.06.025. [Epub ahead of print] PubMed PMID: 27423367

  • Gajewski BJ, Reese CS, Colombo J, Carlson SE. Commensurate Priors on a Finite  Mixture Model for Incorporating Repository Data in Clinical Trials. Stat Biopharm Res. 2016;8(2):151-160. Epub 2016 Jun 2. PubMed PMID: 27347357; PubMed Central PMCID: PMC4915595

  • Moeller KE, Din A, Wolfe M, Holmes G.  Psychotropic medication use in hospitalized patients with borderline personality disorder. Mental Health Clinician. 2016 Mar; 6(2):68-74.

  • D'Silva LJ, Staecker H, Lin J, Sykes KJ, Phadnis MA, McMahon TM, Connolly D, Sabus CH, Whitney SL, Kluding PM. Retrospective data suggests that the higher prevalence of benign paroxysmal positional vertigo in individuals with type 2 diabetes is mediated by hypertension. J Vestib Res. 2016;25(5-6):233-9. doi: 10.3233/VES-150563. PubMed PMID: 26890424; PubMed Central PMCID: PMC4791946

  • Johnson SG, Byrne MD, Christie B, Delaney CW, LaFlamme A, Park JI, Pruinelli L, Sherman SG, Speedie S, Westra BL. Modeling Flowsheet Data for Clinical Research. AMIA Jt Summits Transl Sci Proc. 2015 Mar 25;2015:77-81. eCollection 2015. PubMed PMID: 26306244; PubMed Central PMCID: PMC4525247
  • Kluding PM, Denton J, Jamison TR, Brooks W, Blackwell K, Lantos JD, Waitman LR, McMahon TM, Choudhary A, Bott MJ, Greiner A, Klaus S, O'Brien-Ladner A, Aaronson LS, Burns J, Barohn R. Frontiers: Integration of a Research Participant  Registry with Medical Clinic Registration and Electronic Health Records. Clin Transl Sci. 2015 Oct;8(5):405-11. doi: 10.1111/cts.12309. Epub 2015 Aug 3. PubMed PMID: 26243261; PubMed Central PMCID: PMC4673893
  • Kanaan SF, Waitman LR, Yeh HW, Arnold PM, Burton DC, Sharma NK. Structural equation model analysis of the length-of-hospital stay after lumbar spine surgery. Spine J. 2015 Apr 1;15(4):612-21. doi: 10.1016/j.spinee.2014.11.001. Epub 2014 Nov 13. PubMed PMID: 25463975; PubMed Central PMCID: PMC4502957

  • Adagarla B, Connolly DW, McMahon TM, Nair M, VanHoose LD, Sharma P, et al. SEINE: Methods for Electronic Data Capture and Integrated Data Repository Synthesis with Patient Registry Use Cases. 2015; Available from: http://library.ks.gov/xmlui/handle/2271/1303
  • Kanaan SF, Yeh HW, Waitman RL, Burton DC, Arnold PM, Sharma NK. Predicting discharge placement and health care needs after lumbar spine laminectomy. J Allied Health. 2014 Summer;43(2):88-97. PubMed PMID: 24925036; PubMed Central PMCID: PMC4679198

  • Waitman LR, Aaronson LS, Nadkarni PM, Connolly DW, Campbell JR. The Greater Plains Collaborative: a PCORnet Clinical Research Data Network. J Am Med Inform Assoc. 2014 Jul-Aug;21(4):637-41. doi: 10.1136/amiajnl-2014-002756. Epub 2014 Apr 28. PubMed PMID: 24778202; PubMed Central PMCID: PMC4078294
  • Huser V, Cimino JJ. Desiderata for healthcare integrated data repositories based on architectural comparison of three public repositories. AMIA Annu Symp Proc. 2013 Nov 16;2013:648-56. eCollection 2013. PubMed PMID: 24551366; PubMed Central PMCID: PMC3900207

  • Connolly DW, Adagarla B, Keighley J, Waitman LR. Integrating R efficiently to allow secure, interactive analysis within a clinical data warehouse. In: The 8th International R User Conference Vanderbilt University [Internet]. p. 12–5. Available from: https://informatics.kumc.edu/work/raw-attachment/wiki/KUBMIPresentations...

Our work in developing the Greater Plains Collaborative (GPC) and HERON (i2b2) at the University of Kansas Medical Center is described in the following publication - 

Waitman LR, Aaronson LS, Nadkarni PM, Connolly DW, Campbell JR. The Greater Plains Collaborative: a PCORnet Clinical Research Data Network. J Am Med Inform Assoc. 2014 Jul-Aug;21(4):637-41. doi: 10.1136/amiajnl-2014-002756. Epub 2014 Apr 28. PubMed PMID: 24778202; PubMed Central PMCID: PMC4078294

The following publications cite our GPC/HERON efforts:
  • Bokov A, Manuel L, Cheng C, Bos A, Tirado-Ramos A. Denormalize and Delimit: How not to Make Data Extraction for Analysis More Complex than Necessary. Procedia Computer Science. 2016 Dec 31; 80: 1033-41.

  • Marsolo, K. "Informatics to Support Learning Networks and Distributed Research Networks." In Pediatric Biomedical Informatics, pp. 179-201. Springer Singapore, 2016.

  • McEwan R, Melton GB, Knoll BC, Wang Y, Hultman G, Dale JL, Meyer T, Pakhomov SV. NLP-PIER: A Scalable Natural Language Processing, Indexing, and Searching Architecture for Clinical Notes. AMIA Jt Summits Transl Sci Proc. 2016 Jul 20;2016:150-9. eCollection 2016. PubMed PMID: 27570663; PubMed Central PMCID: PMC5001745

  • Han D, Wang S, Jiang C, Jiang X, Kim HE, Sun J, Ohno-Machado L. Trends in biomedical informatics: automated topic analysis of JAMIA articles. Journal of the American Medical Informatics Association. 2015 Nov 1;22(6):1153-63.

  • Kluding PM, Denton J, Jamison TR, Brooks W, Blackwell K, Lantos JD, Waitman LR, McMahon TM, Choudhary A, Bott MJ, Greiner A, Klaus S, O'Brien-Ladner A, Aaronson LS, Burns J, Barohn R. Frontiers: Integration of a Research Participant  Registry with Medical Clinic Registration and Electronic Health Records. Clin Transl Sci. 2015 Oct;8(5):405-11. doi: 10.1111/cts.12309. Epub 2015 Aug 3. PubMed PMID: 26243261; PubMed Central PMCID: PMC4673893

  • Weber GM. Federated queries of clinical data repositories: Scaling to a national network. J Biomed Inform. 2015 Jun;55:231-6. doi: 10.1016/j.jbi.2015.04.012. Epub 2015 May 6. PubMed PMID: 25957825; PubMed Central PMCID: PMC4464929

  • Marsolo K, Margolis PA, Forrest CB, Colletti RB, Hutton JJ. A Digital Architecture for a Network-Based Learning Health System: Integrating Chronic Care Management, Quality Improvement, and Research. EGEMS (Wash DC). 2015 Aug 17;3(1):1168. doi: 10.13063/2327-9214.1168. eCollection 2015. PubMed PMID: 26357665; PubMed Central PMCID: PMC4562738

  • Rosa C, Campbell AN, Miele GM, Brunner M, Winstanley EL. Using e-technologies  in clinical trials. Contemp Clin Trials. 2015 Nov;45(Pt A):41-54. doi: 10.1016/j.cct.2015.07.007. Epub 2015 Jul 12. PubMed PMID: 26176884; PubMed Central PMCID: PMC4648297

  • van Soest JP, Dekker AL, Roelofs E, Nalbantov G. Application of machine learning for multicenter learning. InMachine Learning in Radiation Oncology 2015 (pp. 71-97). Springer International Publishing.

  • Meeker D, Jiang X, Matheny ME, Farcas C, D'Arcy M, Pearlman L, Nookala L, Day  ME, Kim KK, Kim H, Boxwala A, El-Kareh R, Kuo GM, Resnic FS, Kesselman C, Ohno-Machado L. A system to build distributed multivariate models and manage disparate data sharing policies: implementation in the scalable national network  for effectiveness research. J Am Med Inform Assoc. 2015 Nov;22(6):1187-95. doi: 10.1093/jamia/ocv017. Epub 2015 Jul 3. PubMed PMID: 26142423; PubMed Central PMCID: PMC4639714